Heymut Omran Selected Research

Ciliary Motility Disorders (Primary Ciliary Dyskinesia)

1/2022	Limitations of Nasal Nitric Oxide Measurement for Diagnosis of Primary Ciliary Dyskinesia with Normal Ultrastructure.
10/2020	A novel hypomorphic allele of Spag17 causes primary ciliary dyskinesia phenotypes in mice.
1/2020	Motile ciliopathies.
1/2020	SPEF2- and HYDIN-Mutant Cilia Lack the Central Pair-associated Protein SPEF2, Aiding Primary Ciliary Dyskinesia Diagnostics.
1/2020	Efficacy and safety of azithromycin maintenance therapy in primary ciliary dyskinesia (BESTCILIA): a multicentre, double-blind, randomised, placebo-controlled phase 3 trial.
1/2020	A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance.
1/2018	Mutations in C11orf70 Cause Primary Ciliary Dyskinesia with Randomization of Left/Right Body Asymmetry Due to Defects of Outer and Inner Dynein Arms.
1/2017	Mutations in PIH1D3 Cause X-Linked Primary Ciliary Dyskinesia with Outer and Inner Dynein Arm Defects.
1/2017	Mutation of serine/threonine protein kinase 36 (STK36) causes primary ciliary dyskinesia with a central pair defect.
7/2016	Study protocol, rationale and recruitment in a European multi-centre randomized controlled trial to determine the efficacy and safety of azithromycin maintenance therapy for 6 months in primary ciliary dyskinesia.

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Heymut Omran Research Topics

Disease

26	Ciliary Motility Disorders (Primary Ciliary Dyskinesia) 01/2022 - 07/2005
8	Ciliopathies 01/2022 - 04/2008
6	Neoplasms (Cancer) 01/2021 - 05/2008
4	Infections 01/2021 - 01/2013
4	Situs Inversus 11/2020 - 03/2012
4	Bronchiectasis 01/2020 - 01/2005
4	Hydrocephalus (Hydrocephaly) 11/2019 - 09/2004
4	Respiratory Tract Infections (Respiratory Tract Infection) 10/2019 - 07/2016
3	Retinitis Pigmentosa (Pigmentary Retinopathy) 08/2015 - 03/2005
2	Lung Diseases (Lung Disease) 01/2021 - 06/2014
2	Male Infertility (Male Sterility) 01/2021 - 05/2006
2	Astrocytoma (Pilocytic Astrocytoma) 11/2011 - 05/2008
2	Polycystic Kidney Diseases (Polycystic Kidney Disease) 08/2009 - 05/2006
2	Cystic Kidney Diseases (Cystic Kidney Disease) 08/2009 - 12/2005
1	Seizures (Absence Seizure) 01/2021
1	Virus Diseases (Viral Diseases) 01/2021
1	Inflammation (Inflammations) 01/2021
1	Shock 01/2021
1	Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome) 01/2021
1	Cystic Fibrosis (Mucoviscidosis) 01/2020
1	Crisponi syndrome 01/2020
1	Cough 01/2019
1	Jeune syndrome 03/2018
1	Halitosis 01/2018
1	Infertility (Sterility) 01/2018
1	Neutropenia 01/2018
1	Respiratory Insufficiency (Respiratory Failure) 01/2018
1	Ewing Sarcoma (Sarcoma, Ewing) 01/2018
1	Tyrosine Kinase 2 Deficiency 11/2016
1	Abscess 11/2016
1	Eczema 11/2016
1	Body Weight (Weight, Body) 07/2016
1	Respiratory Tract Diseases (Respiratory Tract Disease) 07/2016
1	Hearing Loss (Hearing Impairment) 07/2016
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2016
1	Asthma (Bronchial Asthma) 01/2016
1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 12/2015
1	Paralysis (Palsy) 05/2012
1	Neurofibromatosis 1 (Neurofibromatosis Type I) 11/2011
1	Brain Neoplasms (Brain Tumor) 03/2011
1	Otitis Media 03/2011
1	Metabolic Diseases (Metabolic Disease) 12/2010
1	Hemorrhage 05/2010
1	Type III Leukocyte Adhesion Deficiency 05/2010

Drug/Important Bio-Agent (IBA)

16	Dyneins (Dynein)IBA 01/2022 - 03/2006
12	Proteins (Proteins, Gene)FDA Link 11/2020 - 12/2005
5	Axonemal DyneinsIBA 01/2022 - 09/2004
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2022 - 05/2012
3	Messenger RNA (mRNA)IBA 01/2021 - 05/2008
3	Anti-Bacterial Agents (Antibiotics)IBA 01/2020 - 01/2015
3	Azithromycin (Zithromax)FDA LinkGeneric 01/2020 - 07/2016
2	RNA (Ribonucleic Acid)IBA 01/2021 - 01/2019
2	Nonsense Codon (Nonsense Mutation)IBA 10/2020 - 01/2018
2	MacrolidesIBA 01/2020 - 07/2016
2	Small Interfering RNA (siRNA)IBA 01/2018 - 05/2008
2	Oxidoreductases (Dehydrogenase)IBA 01/2018 - 03/2006
2	CytokinesIBA 11/2016 - 01/2016
2	Retinaldehyde (Retinal)IBA 08/2015 - 03/2005
2	EnzymesIBA 12/2010 - 05/2010
1	Transcription Factors (Transcription Factor)IBA 01/2021
1	Nucleic AcidsIBA 01/2021
1	Interferon Type IIBA 01/2021
1	InterferonsIBA 01/2021
1	Adenosine Triphosphatases (ATPase)IBA 11/2020
1	Adenylate KinaseIBA 11/2020
1	NIMA-Related KinasesIBA 01/2020
1	Protein Kinases (Protein Kinase)IBA 01/2020
1	Cytokine Receptors (Cytokine Receptor)IBA 01/2020
1	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 01/2020
1	Forkhead Transcription Factors (Forkhead Box Proteins)IBA 11/2019
1	2- hydroxy- N- (3- (trifluoromethyl)phenyl)benzamideIBA 01/2019
1	Selenium-Binding ProteinsIBA 01/2018
1	methylmercaptan (methanethiol)IBA 01/2018
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2017
1	Immunoglobulin E (IgE)IBA 11/2016
1	Interferon LambdaIBA 11/2016
1	Antiviral Agents (Antivirals)IBA 11/2016
1	TabletsIBA 07/2016
1	ManganeseIBA 12/2015
1	Transferrin (beta 2 Transferrin)IBA 12/2015
1	RNA Precursors (Precursor, mRNA)IBA 08/2015
1	UbiquitinIBA 08/2015
1	Proteasome Endopeptidase Complex (Proteasome)IBA 08/2015
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 08/2015
1	CyclinsIBA 06/2014
1	GuanosineIBA 04/2013
1	Proto-Oncogene Proteins B-rafIBA 11/2011
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 11/2011
1	raf KinasesIBA 06/2011
1	Pharmaceutical PreparationsIBA 06/2011
1	TitaniumIBA 03/2011
1	IntegrinsIBA 05/2010

Therapy/Procedure

6	Therapeutics 01/2021 - 01/2005
2	Extracorporeal Membrane Oxygenation 01/2021 - 01/2018
1	Cell Transplantation 01/2021
1	Tracheostomy 10/2019
1	Lung Transplantation 01/2019
1	Hematopoietic Stem Cell Transplantation 01/2018
1	Ventriculoperitoneal Shunt 01/2013
1	Middle Ear Ventilation (Tympanostomy) 03/2011